In the pharmacokineticsDiY part 1 the numerical approach of pharmacokinetic calculations was explained. Using relative simple formulas implemented in a spreadsheet the concentrations of a drug could be calculated following variable drug input protocols. The Eleveld model for propofol was used. This was not without a reason. Douglas Eleveld and co-authors analyzed the data from numerous other […]
Pharmocokinetics DiY part 2 Read More »
part 1:building and verifying the spreadsheet This blog is about pharmacokinetics: Do It Yourself. Only a bit of knowledge of using spreadsheets is required. If you read publications on pharmacokinetics you will have noticed that the model parameters are usually presented in two different notations: clearances V1,V2,V3,Cl,Cl2,Cl3 and time-constants(V1,k10,k21,k12,k13,k31). For a 3 compartment open model
Pharmacokinetics DiY Read More »
My name is Stefan Schraag. Since 2008 I have been chairing the Board of EuroSIVA, a handpicked selection of experts in the field of clinical pharmacology, research and monitoring. Together, we have achieved to establish a team of expertise in many areas of intravenous anaesthesia and target-controlled infusion (TCI). Over the years, this team has
A message from the chairman Read More »
Using my prerogative as webmaster I open this blog to inform you on the purpose and features of the blog. In the Eurosiva-blog the individual board members will write what keeps them busy or what they think is interesting for IV and not so IV enthusiast colleagues. We plan to update this post at least
What to expect: the pre-blog Read More »
