Dr. Hugo E.M. Vereecke (°04/07/1972) became a medical doctor at the Ghent University, Belgium (1997) and consultant anesthesiologist (2002) at the University Hospital Ghent, Belgium. After finalizing his PhD Thesis (2007) on improving anesthetic drug titration using neuro-physiological monitoring, he proceeded an academic career at the University Medical Center Groningen (UMCG) (2010-current), the Netherlands, where […]
Dr. Hugo E.M. Vereecke Read More »
Why are we still talking about volatile anaesthesia? Why do anaesthetists feel comfortable with sticking to old practice and don’t feel the need to progress? And why does the medical literature offer so little to support this change?I remember when I was teaching a trainee during the end of last year. He was fairly advanced
TIVA vs Volatiles: The eternal debate Read More »
Alain Borgeat was clinically working as Head of the Anesthesiology Department, Balgrist University Hospital Zurich, Switzerland with the main focus on Regional Anesthesia and Perioperative Pain Medicine. Since his retirement he works as Senior Research Consultant at the Balgrist Campus, University of Zurich. He was chairman and initiator of the annual EUROSIVA Winter Symposium in
Dr Nick Sutcliffe is a UK trained senior clinician with more than 30 years of experience in the fields of Medicine and Anaesthesia. His clinical interests include Intensive Care Medicine (ICM) and Total Intravenous Anaesthesia (TIVA). He is a recognised specialist in TIVA and regularly gives lectures and workshops, both nationally and internationally. He is
Not surprisingly, Luc Barvais from the Erasme University in Bruxelles was the initiator of the development of a local Target Controlled Infusion (TCI) system. He made a major contribution to the teaching of TCI with the very frequently cited and downloaded publication. We encourage you to take notice from this downloadable publication. Tips-and-Tricks-Acta-2013 From TCI
Until my retirement, just before the Covid pandemic, I was clinically working as a cardio-thoracic anaesthesiologist at the Leiden University Medical Centre with a special interest in paediatric anaesthesia for children with congenital heart disease(CHD). The interest in anaesthesia for CHD was certainly fuelled by the many CHD missions to Surinam. Another clinical highlight and
The incentive of these pharmacokinetic DiY blogs was to give colleagues that have an interest in pharmacokinetics and pharmacodynamics a relative simple tool to use published pk/pd models and make simulations that can be used to deepen the understanding of the tools like TCI that we use in daily practice to perform anaesthesia. We have
Pharmacokinetics DiY part 4 (effect compartment control) Read More »
In part 1 I have explained how a relative simple spreadsheet can produce the concentration of an intravenous drug dose with given pharmacokinetic parameters that describe a 2 or 3 compartment model. In part 2, target controlled infusion(TCI) for blood control has been introduced together with a method to use two pharmcokinetic models in one
Pharmacokinetics DiY part 3 (+Pharmacodynamics) Read More »
Last week I was at the dentist needing a minor procedure that involved having a local anaesthetic. As the I was sitting in the dental chair receiving the injection and experiencing the numbness spreading, I was thinking about the effect site. The concept of the effect site was first described by Holford and Sheiner [1]
A reflection on the effect site Read More »
In the pharmacokineticsDiY part 1 the numerical approach of pharmacokinetic calculations was explained. Using relative simple formulas implemented in a spreadsheet the concentrations of a drug could be calculated following variable drug input protocols. The Eleveld model for propofol was used. This was not without a reason. Douglas Eleveld and co-authors analyzed the data from numerous other
Pharmocokinetics DiY part 2 Read More »
