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Lost in LOC. Titrating to effect. What does it reveal? Dr. Hernán Boveri, Italian Hospital of Buenos Aires, Argentina. Saturday 20 January 9:00-9:30 Currently, propofol is the most widely used intravenous anesthetic drug capable of providing safe general anesthesia. Propofol can be administered using different techniques including target-controlled infusion (TCI).One of the greatest strengths of […]

The different models implemented in TCI:how it happend and who is responsible Stefan Schraag Saturday 10:30-11:00 Who safeguards PK models? It is a tricky task for most to develop a pharmacokinetic model. It gets even more difficult to publish one without any typos. And then, once you have achieved that, what to do with it

Why Total Intravenous Anaesthesia (TIVA) An overview on aspects of patient outcome, oncology, and the environment. Nick Sutcliffe Friday 19 January 8:30-9:00 Introduction The safety of surgery under anaesthesia has improved markedly over the last century. New drugs and improved equipment have resulted in more accurate dosing and reduced side effects. As mortality has improved,

Multimodal anesthesia and multimodal sedation: is two times one more than two? Francisco Lobo Friday 19 January 10:30-11:00 The state of General Anesthesia comprises unconsciousness, amnesia, analgesia/antinociception and immobility accompanied by physiological stability. Classically, this drug-induced reversible state has been achieved with the use of basic interactions between hypnotic drugs, opioids and muscular relaxants; the

time Friday 19 January presenter 08:00-8:15 Registration 08:15-08:30 Chairmans welcome, introduction and practical issues Alain Borgeat 08:30-09:00 Why TIVA? An overview on aspects of patient outcome, oncology, and the environment. Nick Sutcliffe 09:00-09:30 The Eleveld model dissected Extended in the afternoon workshop Hugo Vereecke 09:30-10:00 With a hammer everything looks like a nail How to

The Eleveld model dissected Prof. Dr. Hugo Vereecke, University of Groningen, The Netherlands Friday 19 January 9:00-9:30 In 2018, Douglas Eleveld, from the University of Groningen,  published a new PKPD model for propofol based on the “open TCI initiative” database.1 This database, initiated by S. Shafer and C. Minto, combined a large amount of raw data

Patient-Maintained Sedation Smart pharmacologic concepts beyond the OR Gavin NC Kenny Friday 19 January 11:00-11:30 Conscious sedation allows patients to undergo procedures which they would otherwise be unable to tolerate. The sedation must not contribute any morbidity or mortality to the procedure and ideally should be safe when used by surgeons and physicians as well

Multimodal monitoring to guide TIVA:more windows more light? Luc Barvais MD, PhD1 and Sean Coeckelenbergh, MD2 Saturday 20 January 8:30-9:00 Erasme University Hospital, Brussels Paul Brousse Hospital, Paris Improving TIVA by personalizing monitoring TCI titration is very important in the daily clinical anaesthesia practice to decrease the risk of agitation and sometimes delirium in the postoperative

Measuring online exhaled propofol: – feasible, useful, the future of TIVA, or a toy from the industry? Johan Raeder1,2 Saturday  9:30- 10:00 Co-Authors: Martin Rygh Braathen1,2,  Ivan Rimstad2, Terje Dybvik2 Ståle Nygård3 1 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway 2Dept. of Anaesthesiology, Division of Critical Care, Oslo University Hospital, Oslo, Norway 3 Dept.

With a Hammer everything looks like a Nail How to use Tivatrainer Frank Engbers Friday 19 January 9:00-9:30 Initially, pharmacokinetic models were developed in pharmacological research to elucidate and forecast the temporal profile of drug concentrations upon administration to the body. The utilization of these models in Target Controlled Infusion pumps involves reverse engineering them