Until my retirement, just before the Covid pandemic, I was clinically working as a cardio-thoracic anaesthesiologist at the Leiden University Medical Centre with a special interest in paediatric anaesthesia for children with congenital heart disease(CHD). The interest in anaesthesia for CHD was certainly fuelled by the many CHD missions to Surinam. Another clinical highlight and […]
The incentive of these pharmacokinetic DiY blogs was to give colleagues that have an interest in pharmacokinetics and pharmacodynamics a relative simple tool to use published pk/pd models and make simulations that can be used to deepen the understanding of the tools like TCI that we use in daily practice to perform anaesthesia. We have
Pharmacokinetics DiY part 4 (effect compartment control) Read More »
In part 1 I have explained how a relative simple spreadsheet can produce the concentration of an intravenous drug dose with given pharmacokinetic parameters that describe a 2 or 3 compartment model. In part 2, target controlled infusion(TCI) for blood control has been introduced together with a method to use two pharmcokinetic models in one
Pharmacokinetics DiY part 3 (+Pharmacodynamics) Read More »
Last week I was at the dentist needing a minor procedure that involved having a local anaesthetic. As the I was sitting in the dental chair receiving the injection and experiencing the numbness spreading, I was thinking about the effect site. The concept of the effect site was first described by Holford and Sheiner [1]
A reflection on the effect site Read More »
In the pharmacokineticsDiY part 1 the numerical approach of pharmacokinetic calculations was explained. Using relative simple formulas implemented in a spreadsheet the concentrations of a drug could be calculated following variable drug input protocols. The Eleveld model for propofol was used. This was not without a reason. Douglas Eleveld and co-authors analyzed the data from numerous other
Pharmocokinetics DiY part 2 Read More »
part 1:building and verifying the spreadsheet This blog is about pharmacokinetics: Do It Yourself. Only a bit of knowledge of using spreadsheets is required. If you read publications on pharmacokinetics you will have noticed that the model parameters are usually presented in two different notations: clearances V1,V2,V3,Cl,Cl2,Cl3 and time-constants(V1,k10,k21,k12,k13,k31). For a 3 compartment open model
Pharmacokinetics DiY Read More »
My name is Stefan Schraag. Since 2008 I have been chairing the Board of EuroSIVA, a handpicked selection of experts in the field of clinical pharmacology, research and monitoring. Together, we have achieved to establish a team of expertise in many areas of intravenous anaesthesia and target-controlled infusion (TCI). Over the years, this team has
A message from the chairman Read More »
Using my prerogative as webmaster I open this blog to inform you on the purpose and features of the blog. In the Eurosiva-blog the individual board members will write what keeps them busy or what they think is interesting for IV and not so IV enthusiast colleagues. We plan to update this post at least
What to expect: the pre-blog Read More »
