Last week I was at the dentist needing a minor procedure that involved having a local anaesthetic. As the I was sitting in the dental chair receiving the injection and experiencing the numbness spreading, I was thinking about the effect site. The concept of the effect site was first described by Holford and Sheiner [1] […]
A reflection on the effect site Read More »
In the pharmacokineticsDiY part 1 the numerical approach of pharmacokinetic calculations was explained. Using relative simple formulas implemented in a spreadsheet the concentrations of a drug could be calculated following variable drug input protocols. The Eleveld model for propofol was used. This was not without a reason. Douglas Eleveld and co-authors analyzed the data from numerous other
Pharmocokinetics DiY part 2 Read More »
